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高冠斌

 

高冠斌,副研究员、博士生导师

 

基本情况

出生年月:1987-01        籍贯:湖北随州

最高学历:武汉理工大学  工学博士;

工作单位:武汉理工大学 材料复合新技术国家重点实验室

联系地址:武汉市洪山区珞狮路122号武汉理工大学西院新材所320-2

联系电话:+86-15827567674

Emailgbgao@whut.edu.cn


研究领域

1. 多尺度手性纳米生物界面材料调控多肽/蛋白构象;

2. 手性纳米材料的生物医学新效应、新应用;

3. 用于阿尔兹海默病(AD)和帕金森病(PD)诊疗的手性纳米生物材料;

4. 用于重大疾病诊疗的近红外II区荧光成像材料


教育经历

2010/092016/06,武汉理工大学,材料物理与化学,博士(硕博),导师:孙涛垒

2006/092010/06,武汉纺织大学,高分子材料与工程, 工学学士


工作经历

2019/09-至今          武汉理工大学,材料复合新技术国家重点实验室        副研究员、博士生导师

2018/09-2019/09     武汉理工大学,材料复合新技术国家重点实验室        副研究员、硕士生导师

2016/07-2018/09     武汉理工大学,材料复合新技术国家重点实验室        助理研究员


科研项目

1.   国家自然科学基金面上项目,21975191,智能响应性手性纳米生物界面材料调控多肽/蛋白质构象,2020/01/01-2023/12/3165万元,在研,主持

2.   国家自然科学基金青年科学基金项目,21805218,多尺度微纳米手性界面Aβ聚集及纤维化调控机制研究,2019/01/01-2021/12/3126万元,在研,主持

3.   湖北省自然科学基金青年项目,2018CFB348,纳米手性界面调控Aβ聚集及纤维化,2018/03/19-2019/12/313万元,在研,主持

4.   横向科技项目(20192h0118),深圳深见医药科技有限公司,SA1SA2药物疾病模型横向委托开发(2019-4201-28-000279),2019/06/01-2024/05/31300万元,在研,主持

5.   横向科技项目(20181h0232),深圳广行科学研究有限公司,SA药物疾病模型横向委托开发(2018-4201-13-001190), 2018/06-2021/12100万元,在研,主持


科研奖励

1.  2019/11    入选2019年中国科协优秀中外青年交流计划


代表性论文*通讯作者)

1.  Xintong Tang, Guanbin Gao*, Ting Zhang, Jianhang Li, Meng Yu, Meng He and Taolei Sun*, Charge Effects at Nano-Bio interfaces: A Model of Charged Gold Nanoclusters on Amylin Fibrillation, Nanoscale, 2020, 12, 18834-18843.

2.  Wenkang Zhang, Guanbin Gao*, Zhongjie Ma, Zhuoying Luo, Meng He and Taolei Sun*, Au23(CR)14 Nanocluster Restores Fibril Aβ’s Unfolded State with Abolished Cytotoxicity and Dissolves Endogenous Aβ Plaques, Natl. Sci. Rev., 2020, 7(4), 763-774.

3.  Zhuoying Luo, Guanbin Gao*, Zhongjie Ma, Qian Liu, Xiaobing Gao, Xintong Tang, Zhenxing Gao, Chaoyang Li* and Taolei Sun*, Cichoric Acid from Witloof Inhibit Misfolding Aggregation and Fibrillation of hIAPP, Int. J. Bio. Macromol., 2020, 148, 1272-1279.

4.  Wenkang Zhang, Meng Yu, Wenbo Zhu, Liang Wang, Juncheng Wang, Feifei Yang, Jing Li, Guanbin Gao*, Temperature-Controlled β-Crystal-to-α-Crystal Phase Transition of HgS Nanoparticles, J. Nanosci. Nanotech., 2020, 20(4), 2567-2572;

5.  Jinqi Hu, Guanbin Gao*, Meng He*, Qiang Yin, Xiaobing Gao, Haixing Xu, and Taolei Sun*, The Optimal Route of Gold Nanoclusters Administration in Mice Targeting Parkinson’s Disease, Nanomedicine, 2020, 15(6), 563-580.

6.  Yanping Dai, Mingxi Zhang*, Xiulei Shi, Kang Wang, Guanbin Gao, Lei Shen, Taolei Sun*, Kinetic Study of Aβ(1-42) Amyloidosis in the Presence of Ganglioside-Containing Vesicles. Colloids and Surfaces B: Biointerfaces, 2020, 185, 110615.

7.  Juncheng Wang, Feifei Yang, Guanbin Gao*, and Taolei Sun*, Ag doped HgS Quantum Dots: A pH-tunable Near-Infrared- Fluorescent Nanoprobe, J. Inorg. Mater., 2019, 34(11), 1156-1160.

8.  Zhongjie Ma, Guanbin Gao*, Zhuoying Luo, Xintong Tang and Taolei Sun*, Tuning Chirality Transfer and Amplification of Supraparticles via Solvent Inducing Self-aggregation of Chiral Gold Nanoclusters, J. Phys. Chem. C, 2019, 123, 24973-24978.

9.  Meng He, Xu-Feng Huang, Guanbin Gao, Ting Zhou, Wenting Li, Jinqi Hu, Jia Chen, Jing Li*, Taolei Sun*, Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate, Psychoneuroendocrinology, 2019, 104, 286-299.

10. Jing Li, Rui Chen, Shasha Zhang, Zhongjie Ma, Zhuoying Luo, Guanbin Gao*, Chiral Effect at Nano-Bio Interface: A Model of Chiral Gold Nanoparticle on Amylin Fibrillation, Nanomaterials, 2019, 9(3), 412.

11. Juncheng Wang, Guanbin Gao*, Feifei Yang, Rui Chen, Liang Wang, Wenbo Zhu, Zhongjie Ma, Zhuoying Luo and Taolei Sun*, A Fluorescent Nanoprobe Based on HgS/ZnS Core/Shell Quantum Dots for In-Situ Rapid Visual Detection of Cr3+, J. Nanopart. Res., 2019, 21(3), 50.

12. Feifei Yang, Guanbin Gao*, Juncheng Wang, Rui Chen, Wenbo Zhu, Liang Wang, Zhongjie Ma, Zhuoying Luo and Taolei Sun*, Chiral β-HgS Quantum Dots: Aqueous Synthesis, Optical Properties and Cytocompatibility, J. Colloid. Interf. Sci., 2019, 537, 422-430.

13. Guanbin Gao, Rui Chen, Meng He, Jing Li, Jing Li, Liyun Wang and Taolei Sun*. Gold Nanoclusters for Parkinson’s Disease Treatment, Biomaterials, 2019, 194, 36-46.

14. Shan Wu, Guanbin Gao*, Shasha Zhang, Wenbo Zhu, Liang Wang, Rui Chen, Wenkang Zhang, Juncheng Wang, Feifei Yang; Jing Li, Lei Shen, Taolei Sun*, Mixed-solvent precipitation: a facile approach for nanoparticle self-assembled monolayers, Appl. Surf. Sci., 2019, 465, 526-531.

15. Kang Liu, Guanbin Gao*, Taolei Sun*, β-HgS Quantum Dots: Preparation, Properties and Applications, Prog. Chem., 2017, 29, 776-784.

16. Xuejiao Hu, Guanbin Gao*, Mingxi Zhang*, Gold Nanorods—from Controlled Synthesis and Modification to Nano-biological and Biomedical Applications, Acta Phys. -Chim. Sin., 2017, 33, 1324-1337.

17. Guanbin Gao, Mingxi Zhang, Dejun Gong, Rui Chen, Xuejiao Hu and Taolei Sun*. The size-effect of gold nanoparticles and nanoclusters in the inhibition of amyloid-β fibrillation. Nanoscale, 2017, 9, 4107-4113.

18. Xuesong Lv, Zhixiong Huang*, Mingxian Shi*, Yun Fan, Guanbin Gao*, Composition Distribution, Damping and Thermal Properties of the Thickness-Continuous Gradient Epoxy/Polyurethane Interpenetrating Polymer Networks, Appl. Sci. -Basel, 2017, 7, 135.

19. Guanbin Gao, Dejun Gong, Mingxi Zhang* and Taolei Sun*. Chiral gold nanoclusters: a new near-infrared fluorescent probe. Acta Chim. Sinica, 2016, 74, 363-368.

20. Dejun Gong, Guanbin Gao, Mingxi Zhang* and Taolei Sun, Chiral Gold Nanoclusters: Synthesis, Properties and Biological Application, Prog. Chem., 2016, 28, 296-307.

21. Xuesong Lv*, Zhixiong Huang, Chi Huang, Minxian Shi, Guanbin Gao, Quanqin Gao, Damping properties and the morphology analysis of the polyurethane/epoxy continuous gradient IPN materials, Compos. Part B-Eng., 2016, 88, 139-149

22. Xuesong Lv*, Zhixiong Huang*, Minxian Shi, Yun Fan, Guanbin Gao*, Self-gradient mechanism, morphology and damping analysis of a thickness continuous gradient epoxy-polyurethane interpenetrating polymer network, RSC Adv., 2016, 6, 111688-111701.

23. Guanbin Gao, Mingxi Zhang, Pei Lu, Guanlun Guo, Dong Wang and Taolei Sun*. Chirality-assisted ring-like aggregation of Aβ(1-40) at liquid-solid interfaces: a stereoselective two-step assembly process. Angew. Chem. Int. Ed., 2015, 54, 2245-2250.

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通讯地址:湖北省武汉市武昌区洪山珞狮路122号 (中国 武汉 430070)

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电话:027-87884448

E-mail:sklwut@whut.edu.cn