高冠斌，教授、博士生导师
一、基本情况
出生年月：1987-01 籍贯：湖北随州
最高学历：武汉理工大学 工学博士；
工作单位：武汉理工大学 材料复合新技术国家重点实验室
联系地址：武汉市洪山区珞狮路122号武汉理工大学西院新材所320-2
联系方式：gbgao@whut.edu.cn
二、教育经历
2010/09–2016/06，武汉理工大学，材料物理与化学，博士(硕博)，导师：孙涛垒
2006/09–2010/06，武汉纺织大学，高分子材料与工程， 工学学士
三、工作经历
2022/09-至 今 武汉理工大学材料复合新技术国家重点实验室 教授、博士生导师
2018/09-2022/09 武汉理工大学材料复合新技术国家重点实验室 副教授、硕士生导师
2016/07-2018/09 武汉理工大学材料复合新技术国家重点实验室 助理研究员
四、研究领域
1. 多尺度手性纳米生物界面材料调控多肽/蛋白构象；
2. 手性纳米材料的生物医学新效应、新应用；
3. 用于阿尔兹海默病(AD)和帕金森病(PD)诊疗的手性纳米生物材料；
4. 用于重大疾病诊疗的近红外II区荧光成像材料
五、科研项目(不多于10项)
1. 国家自然科学基金面上项目，52273110，精确构筑纳微仿生界面用于精准调控淀粉样蛋白折叠与纤维化，2023/01/01-2026/12/31，53万元，在研，主持
2. 国家自然科学基金面上项目，21975191，智能响应性手性纳米生物界面材料调控多肽/蛋白质构象，2020/01/01-2023/12/31，65万元，在研，主持
3. 国家自然科学基金青年科学基金项目，21805218，多尺度微纳米手性界面Aβ聚集及纤维化调控机制研究，2019/01/01-2021/12/31，26万元，已结题，主持
4. 湖北省自然科学基金面上项目，2021CFB299，用于蛋白构象病诊疗的纳米手性生物界面材料，2021/10/01-202309/30，8万元，在研，主持
5. 湖北省自然科学基金青年项目，2018CFB348，纳米手性界面调控Aβ聚集及纤维化，2018/03/19-2019/12/31，3万元，已结题（结题优秀），主持
6. 中国科协优秀中外青年交流计划，20191kx032，中国科协优秀中外青年交流计划（2019年度）02，2020/07-2021/12，5万元，在研，主持
7. 武汉市知识创新专项（曙光计划），20221j0044，手性纳米伴侣的设计制备及其调控淀粉样蛋白构象性能研究，2022/06-2024/06, 10万元，在研，主持
8. 横向科技项目（20192h0118），SA1和SA2药物疾病模型横向委托开发，2019/06/01-2024/05/31，300万元，在研，主持
9. 横向科技项目（20211h0421a），纳米生物界材料用于蛋白构象病诊疗基础研究，2021/07/01-2026/06/30，200万元，在研，主持
10. 横向科技项目(20181h0232)，SA药物疾病模型横向委托开发, 2018/06-2021/12，100万元，在研，主持
六、代表性论文（*通讯作者）
1. Lin Zhou, Guanbin Gao*, Zhongjie Ma, Zijun Zhang, Zhenhua Gu, Liangchong Yu, Xiaohan Li, Nan Zhang, Limei Qian, Zelin Tao and Taolei Sun*, Gold Nanoclusters Enhance the Efficacy of the Polymer-Based Chaperone in Restoring and Maintaining the Native Conformation of Human Islet Amyloid Polypeptide, ACS Applied Materials & Interfaces, 2023, 15(2),3409-3419.
2. Guanbin Gao*, Xinglin Liu, Zhenhua Gu, Qingxue Mu, Guowei Zhu, Ting Zhang, Cheng Zhang, Lin Zhou, Lei Shen* and Taolei Sun*, Engineering Nanointerfaces of Au25-Clusters for Chaperone-Mediated Peptide Amyloidosis, Nano Letters 2022, 22, 2964-2970.
3. Guanbin Gao*, Guowei Zhu, Liangchong Yu, Zijun Zhang, Ting Zhang, Xinglin Liu, Cheng Zhang, Lin Zhou and Taolei Sun*, Chiral effect on Aβ fibrillation from molecular-scale to nanoscale, Nano Research 2022, 15(7), 6721-6729.
4. Guanbin Gao*, Ting Zhang, Wenkang Zhang, Zhuoying Luo, Zijun Zhang, Zhenhua Gu, Liangchong Yu, Qinxue Mu and Taolei Sun*, High Efficiency and Related Mechanism of Au(RC) Nanoclusters on Disaggregating Aβ fibrils, J. Colloid. Interf. Sci., 2022, 621, 67-76.
5. Cheng Zhang#, Xiaobing Gao#, Wenrui Chen#, Meng He, Yao Yu, Guanbin Gao*, Taolei Sun*, Advances of Gold Nanoclusters for Bioimaging, iScience, 2022, 25, 105022.
6. Meng He#, Jing Yao#, Zijun Zhang#, Ying Zhang, Rui Chen, Zhenhua Gu, XuFeng Huang, Chao Deng, Ruqin Zhou, Jun Fan, Baohua Zhang, Yanqian Xie, Guanbin Gao* and Taolei Sun*, Gold nanoclusters eliminate obesity induced by antipsychotics, Scientific Reports, 2022, 12, 5502.
7. Jun Fan, Ruqin Zhou, Meng He*, Ruoxi Li, Yufeng Zuo, Benben Li, Guanbin Gao* and Taolei Sun*, The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review. Frontiers in Neuroscience, 2022, 16, 947295.
8. Jianhang Li, Guanbin Gao*, Xintong Tang, Meng Yu, Meng He and Taolei Sun*, Isomeric Effect of Nano-Inhibitors on Aβ40 Fibrillation at The Nano-Bio Interface, ACS Applied Materials & Interfaces, 2021, 13, 4, 4894-4904.
9. 余梦, 张子俊, 朱国委, 谷振华, 段玉霖, 余良翀, 高冠斌*, 孙涛垒*. Ag2S基近红外II区荧光量子点的水相合成优化探究[J], 化学学报, 2021,79(10): 1281-1285.
10. Wenkang Zhang, Guanbin Gao*, Zhongjie Ma, Zhuoying Luo, Meng He and Taolei Sun*, Au23(CR)14 Nanocluster Restores Fibril Aβ’s Unfolded State with Abolished Cytotoxicity and Dissolves Endogenous Aβ Plaques, Natl. Sci. Rev., 2020, 7(4), 763-774.
11. Xintong Tang, Guanbin Gao*, Ting Zhang, Jianhang Li, Meng Yu, Meng He and Taolei Sun*, Charge Effects at Nano-Bio interfaces: A Model of Charged Gold Nanoclusters on Amylin Fibrillation, Nanoscale, 2020, 12, 18834-18843.
12. Zhuoying Luo, Guanbin Gao*, Zhongjie Ma, Qian Liu, Xiaobing Gao, Xintong Tang, Zhenxing Gao, Chaoyang Li* and Taolei Sun*, Cichoric Acid from Witloof Inhibit Misfolding Aggregation and Fibrillation of hIAPP, Int. J. Biol. Macromol., 2020, 148, 1272-1279.
13. Wenkang Zhang, Meng Yu, Wenbo Zhu, Liang Wang, Juncheng Wang, Feifei Yang, Jing Li, Guanbin Gao*, Temperature-Controlled β-Crystal-to-α-Crystal Phase Transition of HgS Nanoparticles, J. Nanosci. Nanotech., 2020, 20(4), 2567-2572;
14. Jinqi Hu, Guanbin Gao*, Meng He*, Qiang Yin, Xiaobing Gao, Haixing Xu, and Taolei Sun*, The Optimal Route of Gold Nanoclusters Administration in Mice Targeting Parkinson’s Disease, Nanomedicine, 2020, 15(6), 563-580.
15. 王君诚, 杨菲菲, 高冠斌*, 孙涛垒*, Ag掺杂HgS量子点: 一种pH调谐的近红外Ⅱ区荧光纳米探针, 无机材料学报, 2019, 34(11), 1156-1160.
16. Zhongjie Ma, Guanbin Gao*, Zhuoying Luo, Xintong Tang and Taolei Sun*, Tuning Chirality Transfer and Amplification of Supraparticles via Solvent Inducing Self-aggregation of Chiral Gold Nanoclusters, J. Phys. Chem. C, 2019, 123, 24973-24978.
17. Jing Li, Rui Chen, Shasha Zhang, Zhongjie Ma, Zhuoying Luo, Guanbin Gao*, Chiral Effect at Nano-Bio Interface: A Model of Chiral Gold Nanoparticle on Amylin Fibrillation, Nanomaterials, 2019, 9(3), 412.
18. Juncheng Wang, Guanbin Gao*, Feifei Yang, Rui Chen, Liang Wang, Wenbo Zhu, Zhongjie Ma, Zhuoying Luo and Taolei Sun*, A Fluorescent Nanoprobe Based on HgS/ZnS Core/Shell Quantum Dots for In-Situ Rapid Visual Detection of Cr3+, J. Nanopart. Res., 2019, 21(3), 50.
19. Feifei Yang, Guanbin Gao*, Juncheng Wang, Rui Chen, Wenbo Zhu, Liang Wang, Zhongjie Ma, Zhuoying Luo and Taolei Sun*, Chiral β-HgS Quantum Dots: Aqueous Synthesis, Optical Properties and Cytocompatibility, J. Colloid. Interf. Sci., 2019, 537, 422-430.
20. Guanbin Gao, Rui Chen, Meng He, Jing Li, Jing Li, Liyun Wang and Taolei Sun*. Gold Nanoclusters for Parkinson’s Disease Treatment, Biomaterials, 2019, 194, 36-46.
21. Shan Wu, Guanbin Gao*, Shasha Zhang, Wenbo Zhu, Liang Wang, Rui Chen, Wenkang Zhang, Juncheng Wang, Feifei Yang; Jing Li, Lei Shen, Taolei Sun*, Mixed-solvent precipitation: a facile approach for nanoparticle self-assembled monolayers, Appl. Surf. Sci., 2019, 465, 526-531.
22. 刘康, 高冠斌*, 孙涛垒*, β-HgS 量子点的制备、性质及应用[J], 化学进展, 2017, 29, 776-784.
23. 胡雪娇, 高冠斌*, 张明曦*, 金纳米棒——从可控制备与修饰到纳米生物学与生物医学应用[J]，物理化学学报, 2017, 33, 1324-1337.
24. Guanbin Gao, Mingxi Zhang, Dejun Gong, Rui Chen, Xuejiao Hu and Taolei Sun*. The size-effect of gold nanoparticles and nanoclusters in the inhibition of amyloid-β fibrillation. Nanoscale, 2017, 9, 4107-4113.
25. Xuesong Lv, Zhixiong Huang*, Mingxian Shi*, Yun Fan, Guanbin Gao*, Composition Distribution, Damping and Thermal Properties of the Thickness-Continuous Gradient Epoxy/Polyurethane Interpenetrating Polymer Networks, Appl. Sci. -Basel, 2017, 7, 135.
26. 高冠斌，龚德君，张明曦*，孙涛垒*，手性金纳米团簇：一种新型近红外荧光探针，化学学报，2016，74，363-374.
27. Xuesong Lv*, Zhixiong Huang*, Minxian Shi, Yun Fan, Guanbin Gao*, Self-gradient mechanism, morphology and damping analysis of a thickness continuous gradient epoxy-polyurethane interpenetrating polymer network, RSC Adv., 2016, 6, 111688-111701.
28. Guanbin Gao, Mingxi Zhang, Pei Lu, Guanlun Guo, Dong Wang and Taolei Sun*. Chirality-assisted ring-like aggregation of Aβ(1-40) at liquid-solid interfaces: a stereoselective two-step assembly process. Angew. Chem. Int. Ed., 2015, 54, 2245-2250.
七、奖励与荣誉
1. 2019/11 入选2019年中国科协优秀中外青年交流计划
2. 2021/09 入选2021年武汉理工大学“青年教师十大科技进展”
3. 2022/09 获武汉理工大学“课程思政优秀教师”荣誉称号
