晏乐三，研究员，博士生导师，湖北省高层次人才（青年项目）
个人简介
晏乐三，研究员，博士生导师。主要从事生物医用高分子领域的研究，致力于可降解高分子材料的创新设计与精准合成，及其在肿瘤治疗、心血管疾病干预及炎症疾病防治中的应用。至今，在国际主流期刊上发表SCI论文70余篇。曾荣获/入选湖北省海外高层次人才计划（青年项目）、楚天学子，2020年度中/韩国生物材料协会年青年科学家奖、2022年度英国皇家化学学会Journal of Materials Chemistry B新锐科学家、2015年吉林省自然科学二等奖等。
教育经历
2003.09-2007.07 武汉理工大学，高分子材料与工程专业，学士
2007.09-2013.01 中国科学院长春应用化学研究所，高分子化学与物理，博士
工作经历
2013.02-2014.03 美国约翰霍普金斯大学，博士后
2014.04-2018.02 美国宾夕法尼亚大学，博士后
2018.03-2019.06 美国宾夕法尼亚大学，Research Associate
2019.09-至今 武汉理工大学，材料复合新技术国家重点实验室，研究员
研究领域
1. 生物可降解高分子材料
2. 纳米药物载体及靶向药物递送
3. 纳米探针与分子成像
近期主要科研项目
1．国家重点研发计划项目（2024YFF0508600），2024.12-2029.11，项目骨干
2．湖北省自然科学基金联合基金重点项目（2025AFD037），2025.03-2028.02，主持
3．国家自然科学基金青年项目（52003211），2021-2023，主持
4．湖北省自然科学基金青年项目（2020CFB418），2020-2022，主持
5．湖北省高层次人才青年项目，2022-2026，主持
近期发表论文
1. Yuyue Xiong, Shuai Yang, Yaodong Di, Jinglong Yang, Jing Tu*, Lesan Yan*, GSH-triggered Nitric Oxide Release from Polyurethane Nanocarriers for Gas-Photothermal Synergistic Therapy of Bacterial-infected Wounds. ACS Applied Materials & Interfaces, 2025, 17(17), 25097-25111
2. Qiang Zhang, Jiamin Lin, Jun Li, Yitian Zhou, Zhiqiang Bi, Hao Yang, Wenli Lu, Tianming Lu, Ruoning Qian, Xi Yang, Yuanyuan Guo, Xiaoqing Xin, Lesan Yan*, Shanshan Wang*, Ruogu Qi*, Mitochondrial-Targeted Multifunctional Platinum-Based Nano “Terminal-Sensitive Projectile” for Enhanced Cancer Chemotherapy Efficacy. ACS Nano 2025, 19(9), 8711-8726
3. Jiye Zhao, Dongdong Wang, Xi Zhang, Yaodong Di, Shuai Yang, Lesan Yan*, Preparation of Disulfide/Trisulfide Core-Cross-Linked Polycarbonate Nanocarriers for Intracellular Reduction-Triggered Drug Release, ACS Macro Letters, 2024, 13, 1433-1441
4. Fuqiang Shi, Jie Chen, Lesan Yan*, Jing Tu*, GSH-depleting and H2O2 self-supplying calcium peroxide-based nanoplatforms for efficient bacterial eradication via photothermal enhanced chemodynamic therapy, ACS Applied Materials & Interfaces, 2024, 16(50), 69055-69070
5. Shuangyu Tian, Jinghang Li, Dongdong Wang, Yingchao Han, Honglian Dai, and Lesan Yan*, Sonodynamic-Chemotherapy Synergy with Chlorin e6-based Carrier-free Nanoparticles for Non-Small Cell Lung Cancer, Journal of Materials Chemistry B, 2024,12, 3282-3291
6. Qiang Cheng, Weixing Wang, Xianzhen Dong, Yunhui Chai, Takashi Goto, Rong Tu, Lesan Yan*, Aixi Yu*, and Honglian Dai*, An Adaptable Drug Delivery System Facilitates Peripheral Nerve Repair by Remodeling the Microenvironment, Biomacromolecules, 2024, 25 (3), 1509-1526
7. Xianzhen Dong, Hao Zhang, Ping Duan, Kun Liu, Yifeng Yu, Wenying Wei, Weixing Wang, Yuhang Liu, Qiang Cheng, Xinyue Liang, Yuanfang Huo, Lesan Yan*, Aixi Yu*, and Honglian Dai*, An injectable and adaptable hydrogen sulfide delivery system for modulating neuroregenerative microenvironment, Science Advances, 2023, 9 (51), eadi1078
8. Dongdong Wang, Mu Li, Hanning Zhang, Congshu Feng, Lili Wu, and Lesan Yan*, A Novel Redox-Sensitive Drug Delivery System Based on Trimethyl-Locked Polycarbonate, Biomacromolecules, 2023, 24(9), 4303-4315
9. Jinhai Xie, Shuangyu Tian, Hanning Zhang, Congshu Feng, Yingchao Han, Honglian Dai, and Lesan Yan*, A Novel NQO1 Enzyme-Responsive Polyurethane Nanocarrier for Redox-Triggered Intracellular Drug Release, Biomacromolecules, 2023, 24 (5), 2225-2236
10. Hanning Zhang, Shuangyu Tian, Mu Li, Jinhai Xie, HongLian Dai, Liuyong Hu, and Lesan Yan*, Novel Donor-Acceptor Conjugated Polymer-Based Nanomicelles for Photothermal Therapy in the NIR Window, Biomacromolecules, 2022, 23 (8), 3243-3256
11. Diya Shi, Congshu Feng, Jinhai Xie, Xi Zhang, HongLian Dai, and Lesan Yan*, Recent Progress of Nanomedicine on Secreted Phospholipase A2 as a Potential Therapeutic Target, Journal of Materials Chemistry B, 2022, 10, 7349-7360
12. Lesan Yan, Ahmad Amirshaghaghi, Dennis Huang, Joann Miller, Joel M. Stein, Theresa M. Busch, Zhiliang Cheng*, and Andrew Tsourkas*. Protoporphyrin IX (PpIX)-coated superparamagnetic iron oxide nanoparticle (SPION) nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy. Advanced Functional Materials. 2018, 28, 1707030.
联系方式
电话：15972199746
邮箱：lsyan@whut.edu.cn
工作单位：武汉理工大学材料复合新技术全国重点实验室
联系地址：武汉市洪山区珞狮路122号武汉理工大学马房山校区西院逸夫楼7-5
招生招聘
课题组欢迎具备材料、化学、生物、医学和药学等专业背景的优秀本科、硕士和博士生加盟。有意者请将个人简历发送至晏老师邮箱。
